Design and Analysis of Cross-Over Trials, Second EditionCRC Press, 12/03/2003 - 408 من الصفحات The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include:
The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come. |
المحتوى
1 Introduction | 1 |
2 The 22 CrossOver Trial | 11 |
3 HigherOrder Designs for Two Treatments | 114 |
4 Designs for three or more treatments | 146 |
5 Analysis of continuous data | 193 |
6 Analysis of categorical data | 267 |
7 Bioequivalence trials | 305 |
Appendix A Least squares estimation | 333 |
Appendix B SAS code for assessing ABE IBE and PBE in replicate crossover trials | 338 |
| 342 | |
| 355 | |